Usual layouts, alignment Vs needed Aesthetics

i get that all elements and sections should be spaced evenly however, i find sometimes that bold-uneven-alignment (i’m not talking about broken uneven-alignment) is needed for aesthetic feel.

more often than not if we keep doing the same old alignment we can’t produce new/fresh layouts.

to farther clarify: also i’m not talking about unpractical layout, what i’m saying is if we needed new good/new layouts we need to sacrifice the old alignment thing and be bold and creative with it.

do you think that breaking the old alignment and spacing thing will turn the reviewer off? what’s your take on that?