It all comes down to your design but definitely mixing fonts up (within a sensible reason), hierarchy and styling are critical.
Personally I would always say don’t try and be too over the top. Too often you see (generally weaker) files here trying to be ‘unique’ or ‘creative’ by throwing in some random and brash selections that just end up feeling lost and out of place.
There’s loads of good inspiration sites like this or tutorials etc. like this.