Have you guys started using Flex-box in your themes or templates?

With IE8 and IE9’s global usage falling below 0.7% and 0.5% respectively, you can make a decision to drop support for those. Everything else supports flexbox using one of the two syntax. Though you will have to be aware of quite a few bugs in some of the browsers (mainly IE11): https://github.com/philipwalton/flexbugs